Study size
60 women
Eligibility
Ages 45–58
Duration
12 weeks
Location (Phase 1)
Sydney only
Reviewed by
Bellberry HREC
01 — Why this matters
A demographic the industry forgot.
"I'm doing this for future women who will see these changes in their skin, like my younger sister"
Anna, 56 (participant)
Most of the science behind the products you've been buying for twenty years was tested on women in their twenties.
Women over 45 make up roughly one in four Australian adults. We have the most discerning eye for product quality, the most discretionary income, and we are quietly the largest commercial demographic in beauty. We are also, by some distance, the most under-represented group in dermatological and cosmetic clinical research.
The biology of skin during the menopause transition is mechanistically different from earlier decades. Oestrogen withdrawal affects collagen, hydration, barrier function and pigmentation on a faster trajectory than ageing alone would predict. The research has lagged. That gap is the reason most products feel less effective in mid-life — not because skin has given up, but because the products weren't designed for it.
~30% of dermal collagen is lost in the first five years after menopause.
Brincat et al., Obstetrics & Gynecology, 1987.
This study exists to begin closing that gap. It is not the final word — it is the first chapter of a longer commitment. We believe that women in mid-life deserve products designed with evidence drawn from their own bodies, not extrapolated from someone else's. If you are reading this and feel the same, we would be honoured to have you with us.
An investment in you, not an inconvenience to be compensated.
02 — What you receive
We are not paying participants in cash. We are paying you in product, access, and recognition — because we want this study to attract women who care about their skin's future, not the immediate payout.
A full 12-week supply
During the study · Valued at $1,107
Three months of EXOGLO Serum, supplied at no cost. Three professional AI skin diagnostics, in-clinic or at home. A personalised skin-health report at the close of the study.
Half year supply FREE
On completion · Valued at $2,214
Six months continued supply of EXOGLO Serum, delivered to you, at no cost. This is our thank you. Your time is the most valuable thing you have given us; we'd like to recognise it in kind.
30% lifetime discount
For life · On all EXOGLO products
After your first year, a 30% discount across the EXOGLO range, for life. If you choose to continue, we want the relationship to remain as fair as it began. Optional recognition in the published study findings.
03 — On safety
First, the most important thing.
EXOGLO Serum is not an experimental product. It is a cosmetic skincare product that is already sold across Australia, Japan, and several other markets. It has been through every safety assessment required of a cosmetic product brought to market in this country.
This study is about efficacy — not safety. We are measuring how well the product works in peri- and post-menopausal skin, specifically. Its safety profile is already established by manufacturing, regulatory and post-market record.
To make this completely clear:
✓ Fully compliant with the Therapeutic Goods Administration's standards for cosmetic products in Australia.
✓ All ingredients are listed on the standard INCI register and meet international cosmetic safety standards.
✓ Independently dermatologically tested. Stability tested. Microbiologically tested.
✓ Awarded Poco'ce Best Beauty Award (H1 2025), Japan.
✓ 950+ verified customer reviews on record, with a 4.9 out of 5 rating.
✓ The study itself is reviewed and approved by Bellberry HREC — an independent ethics committee that has overseen more than 11,000 studies in Australia.
✓ The study will be prospectively registered on the Australian New Zealand Clinical Trials Registry (ANZCTR) before the first participant is enrolled.
What this study is, and what it is not.
04 — In clear terms
We are committed to being completely transparent about what you are signing up for. Anything that is not on either of these lists is not part of the study.
What it is
- A clinical study of how well an existing skincare product works in peri- and post-menopausal skin.
- 12 weeks of daily product use, followed by professional measurement at four time points.
- Assessed by standardised AI skin imaging and validated participant-reported questionnaires.
- Reviewed and approved by an independent ethics committee (Bellberry HREC).
- Prospectively registered on the Australian Clinical Trials Registry.
- Designed to be published in a peer-reviewed dermatology journal.
- A real, meaningful commitment over three months.
What it is not
- An experimental drug trial. EXOGLO Serum is a registered cosmetic, not a pharmaceutical.
- A safety study. Safety has been established through standard pre-market and post-market processes.
- A short or casual commitment. We need consistent daily use across all 12 weeks for the data to be valid.
- An anonymous experience. You will work with named clinical and scientific staff, not a black box.
- A trial of an unknown formula. Every ingredient is listed publicly, before you consent.
- A high-pressure environment. You may withdraw at any time, for any reason, with no consequence.
- A cash compensation programme. We thank you in product and access, not currency.
Three months. Four visits. One daily ritual.
05 — How participation works
All four assessments take place at our Sydney clinic. Phase 1 is in-person only, by design — every scan is captured on the same equipment, in the same controlled lighting, by the same trained operator. That standardisation is what makes the data publishable.
Day 0 — Baseline visit
In-clinic in Sydney. AI skin scan, photographs, brief questionnaire. Receive your study supply. Approximately 30 minutes.
Day 28 — First check-in
Return to the clinic. Repeat scan and questionnaire. Quick review of your experience. Continue daily use.
Day 56 — Mid-study
Return to the clinic. Repeat scan and questionnaire. By this point most participants begin to see meaningful change in tone and texture.
Day 84 — Final scan
Final clinic visit. Final scan and questionnaire. Receive your personalised skin-health report. The 12-month supply ships shortly after.
06 — How we'll measure it
The technology, in case you're curious.
A real clinical study needs more than the human eye. We measure your skin using EVE V — an AI skin imaging platform developed by EVELAB Insight, used today by some of the most discerning skincare brands in the world.
EVE V is a multi-spectral imaging system that captures more than ten skin parameters in a single scan — fine lines and wrinkles, pigmentation, texture, redness, evenness, hydration, pore visibility, and structural elasticity. Every measurement is generated by AI models trained on millions of skin images labelled to dermatologists' standards, and validated in peer-reviewed publications including the Society for Investigative Dermatology, the International Society for Biophysics and Imaging of the Skin, and the Journal of Cosmetic Dermatology.
It is also gentle. There are no needles. No swabs. No discomfort. You sit down, the device captures three angles in under a minute, and the system generates your reading in real time. The whole assessment, from arrival to result, takes about twenty minutes.
We chose EVE V because it is the only platform we evaluated that meets both standards we cared about: the clinical rigour the research demands, and the considered, unhurried participant experience our cohort deserves.
EVE V is certified for non-invasive skin imaging analysis. It is not a medical device, and the readings are measurements of skin appearance, not medical diagnoses.
In use today at
Also: Maison KOSÉ LA · The Body Shop · MAKE UP FOR EVER × Sephora · Givenchy
Estée Lauder
Re-Nutriv flagship, Harrods
Dior
AI Skin Analysis
Shiseido
EFFECTIM 3D Analysis
Dr. Barbara Sturm
Spa & Boutiques, globally
EVE V — the device that will measure your skin at every visit.
Who we are looking for. And who we are not.
07 — Eligibility
We are looking for
- Women aged 45 to 58, based in Sydney and able to attend our clinic four times over twelve weeks.
- Perimenopausal (irregular cycles for six months or more) or post-menopausal (no period for twelve months or more).
- Stable in your current skincare routine for at least the last four weeks.
- Willing to commit to twelve consecutive weeks of daily morning and evening use, and four in-clinic assessment visits.
- Genuinely curious about contributing to research that has not been done before — for women like us.
Not the right fit if you
- Are based outside Sydney for Phase 1 (a research register is available — see the application section below).
- Are currently using prescription topical retinoids on the face.
- Have had in-clinic cosmetic procedures (laser, microneedling, fillers, PRP, exosomes) within the last three months.
- Have had Botox to the periorbital area within the last three months.
- Are pregnant, breastfeeding, or planning to become pregnant during the study window.
- Cannot commit to consistent daily use across the full twelve weeks.
- Are joining primarily for the free product. We need participants who care about the data.
What we will do with your data. And what we will never do.
08 — Your data, your dignity
Throughout the study, we will collect AI skin scans, photographs, and answers to validated questionnaires. Here is exactly how that information will and will not be used. You will see this again in the full Participant Information and Consent Form before you sign.
We will
- Use your skin scans and questionnaires to analyse the clinical efficacy of EXOGLO Serum across the cohort.
- Publish the aggregate, de-identified study findings in a peer-reviewed dermatology journal.
- Use anonymised before/after photographs in marketing materials only with your separate, specific written consent — and only where any identifying features (eyes) are obscured if you request it.
- Store de-identified data securely for fifteen years, in line with Australian clinical trial regulations.
- Provide you with your own personalised skin-health report at the end of the study.
We will not
- Sell, license or share your data with any third party.
- Identify you publicly without your specific written consent. Your name is yours.
- Use your photograph in any way you have not specifically agreed to. Image consent is separate from study consent, and you may opt out of it without affecting your participation.
- Use your data to target you with marketing outside the scope of this study.
- Anything beyond what is written in the Participant Information and Consent Form. If we ever wish to expand the use of data, we will come back to you and ask.
09 — Apply
Apply to participate.
If you have read this far, you are exactly the kind of considered, curious participant this study needs.
We read every application personally. Acceptance is not first-come-first-served — we are building a cohort that fairly represents the spectrum of peri- and post-menopausal Australian women.
If you are not selected for this study, we will keep your details on file (with your permission) for future research.
Applications close soon. Study commences July 2026.
Frequently asked.
Is EXOGLO Serum safe? Why are you running a clinical study if it is?
Yes — and this is the most important thing to understand. EXOGLO Serum is a cosmetic skincare product that is already sold across Australia. It meets every safety requirement set by the Therapeutic Goods Administration. Its ingredient list is publicly registered. It has more than 950 verified customer reviews on record.
Clinical studies in cosmetics measure efficacy, not safety. Safety is established before a product is allowed onto the market. This study is asking a different question: how well does this product work, specifically for peri- and post-menopausal women in Australia? That question has never been answered with proper clinical evidence in this country. We are running the study to answer it.
What technology will be used to measure my skin?
We use EVE V, an AI skin imaging platform developed by EVELAB Insight. It is the same system used by Estée Lauder, Dior, Shiseido, Dr. Barbara Sturm, The Body Shop and others in their flagship clinics around the world. EVE V captures over ten skin parameters in a single scan — wrinkles, pigmentation, texture, redness, evenness, hydration, pores, elasticity — using AI models trained on millions of skin images and validated in peer-reviewed dermatology journals.
The scan itself is gentle, non-invasive, and takes about a minute. You sit in front of the device, it captures three angles, and the system generates your reading in real time. The complete visit — including the brief questionnaire — is about twenty minutes.
EVE V is certified for non-invasive skin imaging analysis. It is not a medical device, and the readings are measurements of your skin's appearance, not medical diagnoses.
Will my face be in your advertising?
Only if you specifically choose for it to be. Photograph use in marketing is a separate consent from study participation. You can participate in the full study and never have your image used in any marketing material whatsoever.
If you do choose to allow your photographs to be used, you can request that identifying features (such as eyes) are obscured. Your name will never be published without your explicit written permission, and the relationship between you and any image you appear in is yours to define.
Why no cash compensation?
Two reasons. The first is ethical: large cash payments can become a form of coercion, and the National Statement on Ethical Conduct in Human Research specifically asks researchers to avoid that. The second is practical: we want participants who are joining for the science and for their own skin, not for the cheque. The compensation we have chosen — a year's supply of product, plus a 30% lifetime discount — is genuinely valuable, but it self-selects for women who would actually use and value the product.
What if I have a reaction to the product?
Stop using it immediately and contact the study team. We will review what has happened, document it, and provide medical advice if needed. You can withdraw from the study at any point for any reason, including a reaction — without any negative consequence and without losing any rights you would otherwise have.
The most common adverse reactions to topical skincare are mild and transient: temporary redness, dryness, or a slight tingling, usually in the first one to two weeks. These are uncommon with EXOGLO based on its post-market record, but we will be watching for them.
Why is Phase 1 Sydney-only?
The scientific reason is straightforward: the integrity of monthly facial analysis depends on every scan being captured on the same equipment, under the same lighting conditions, by the same trained operator. Tiny variations in any of those factors introduce noise that obscures the signal we are trying to measure. The cleanest way to control for this in Phase 1 is to bring everyone into a single clinic.
Phase 2 of the study will use a validated decentralised assessment kit — a controlled-light hood and standardised capture protocol that we can ship to participants in other cities. We are working on it now. If you are outside Sydney and would like to be considered for Phase 2, please join the research register above. We will write to you before Phase 2 opens to the public.
Can I keep using my current routine?
Mostly, yes — but with some restrictions. You will need to discontinue any other facial cosmetic actives (other serums, retinoids, vitamin C serums, exfoliants, growth-factor or exosome products) during the 12-week study period, because we need to be able to measure what EXOGLO is doing without confounding inputs. You can and should continue with: a gentle cleanser, a bland moisturiser, and broad-spectrum SPF 30+ sunscreen daily. Stable systemic medication, including menopausal hormone therapy, is fine to continue.
What happens after the study?
Three things. First, you receive your personalised skin-health report. Second, your full year's supply of EXOGLO ships to you. Third, the aggregated, de-identified data is analysed, written up, and submitted to a peer-reviewed dermatology journal. You will be the first to know when it is published — and, if you've opted in, your contribution will be acknowledged.
Who decides who is accepted?
The Principal Investigator (Dr Joshua Chou) and the study coordinator review every application. Acceptance is based on eligibility, fit with the cohort we are trying to build (which fairly represents both peri- and post-menopausal sub-groups), and ability to commit to the full twelve weeks. It is not first-come-first-served.
If you are not accepted, you may still hear from us about future research. With your permission, we keep applicant details on a research register.